GUT FEELINGS: The Hidden Link Between Gut Health and Hormonal Imbalance
By Our Daughters Foundation
GUT FEELINGS: The Hidden Link Between Gut Health and Hormonal Imbalance
By Our Daughters Foundation
1. The Gut Microbiome: Your Internal Ecosystem
Your gut isn’t just a tube for digesting food. It’s home to trillions of bacteria that:
• Help break down food
• Make key nutrients (like B vitamins)
• Train your immune system
• And — importantly — regulate estrogen levels
This bacterial community is called the gut microbiome, and when it’s healthy and diverse, it supports balanced hormones. But when the microbiome is out of balance — a condition called dysbiosis — problems can arise.
2. Estrobolome: The Gut’s Hormone Filte
Inside the gut, a specific group of bacteria known as the estrobolome helps process estrogen. These bacteria produce enzymes (like beta-glucuronidase) that influence how much estrogen is reabsorbed into the bloodstream versus excreted.
When the estrobolome is overactive or underactive, it can lead to:
• Excess circulating estrogen → linked to endometriosis, fibroids, PMS, and breast tendernes
• Too little estrogen → contributing to mood changes, bone loss, and vaginal dryness
So a disrupted gut can directly amplify hormonal imbalances.
3. Inflammation: The Common Denominator
Both gut dysbiosis and endometriosis are associated with chronic inflammation. When the gut barrier is weakened (a condition sometimes called “leaky gut”), it allows inflammatory molecules to pass into the bloodstream. This triggers an immune response — and in people with endometriosis or PCOS, it can worsen pelvic pain, fatigue, and hormonal chaos.
4. What the Research Says
While this field is still developing, early studies have found:
• Women with endometriosis often have altered gut microbiomes compared to those without the condition. [Study: Ata et al., 2019, Scientific Reports]
• A high-fiber, plant-rich diet may help support a more balanced gut flora and improve estrogen metabolism. [Study: Fuhrman et al., 2004, Journal of Nutrition]
• Some researchers are exploring probiotic therapy as a future tool for managing hormone-related conditions.
5. What Can You Do?
You can’t fully control your hormones — but you can support your gut.
Here are some gut-friendly, hormone-supporting habits:
• Eat more fiber: vegetables, fruits, legumes, and seeds
• Avoid excessive sugar and processed foods
• Include fermented foods: yogurt, kefir, sauerkraut, kimchi
• Consider a probiotic — talk to your provider first
• Manage stress — cortisol (the stress hormone) also affects gut balance
• Support liver detoxification (which works with your gut to clear estrogen): eat cruciferous vegetables like broccoli and cauliflower
Final Thoughts
The gut isn’t just about digestion — it’s a key player in how your body handles hormones, pain, and inflammation.
If you’re struggling with endometriosis, PCOS, or unexplained hormone symptoms, supporting your gut might be an empowering place to start.
Want to Learn More?
Here are some helpful articles and research:
• The Gut Microbiome and Estrogen Metabolism – NIH
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471213/
• Gut Microbiota and Endometriosis – Scientific Reports
https://www.nature.com/articles/s41598-019-39645-2
• How the Gut Influences Hormones – Integrative Medicine Journal
1. The Gut Microbiome: Your Internal Ecosystem
Your gut isn’t just a tube for digesting food. It’s home to trillions of bacteria that:
• Help break down food
• Make key nutrients (like B vitamins)
• Train your immune system
• And — importantly — regulate estrogen levels
This bacterial community is called the gut microbiome, and when it’s healthy and diverse, it supports balanced hormones. But when the microbiome is out of balance — a condition called dysbiosis — problems can arise.
2. Estrobolome: The Gut’s Hormone Filte
Inside the gut, a specific group of bacteria known as the estrobolome helps process estrogen. These bacteria produce enzymes (like beta-glucuronidase) that influence how much estrogen is reabsorbed into the bloodstream versus excreted.
When the estrobolome is overactive or underactive, it can lead to:
• Excess circulating estrogen → linked to endometriosis, fibroids, PMS, and breast tendernes
• Too little estrogen → contributing to mood changes, bone loss, and vaginal dryness
So a disrupted gut can directly amplify hormonal imbalances.
3. Inflammation: The Common Denominator
Both gut dysbiosis and endometriosis are associated with chronic inflammation. When the gut barrier is weakened (a condition sometimes called “leaky gut”), it allows inflammatory molecules to pass into the bloodstream. This triggers an immune response — and in people with endometriosis or PCOS, it can worsen pelvic pain, fatigue, and hormonal chaos.
4. What the Research Says
While this field is still developing, early studies have found:
• Women with endometriosis often have altered gut microbiomes compared to those without the condition. [Study: Ata et al., 2019, Scientific Reports]
• A high-fiber, plant-rich diet may help support a more balanced gut flora and improve estrogen metabolism. [Study: Fuhrman et al., 2004, Journal of Nutrition]
• Some researchers are exploring probiotic therapy as a future tool for managing hormone-related conditions.
5. What Can You Do?
You can’t fully control your hormones — but you can support your gut.
Here are some gut-friendly, hormone-supporting habits:
• Eat more fiber: vegetables, fruits, legumes, and seeds
• Avoid excessive sugar and processed foods
• Include fermented foods: yogurt, kefir, sauerkraut, kimchi
• Consider a probiotic — talk to your provider first
• Manage stress — cortisol (the stress hormone) also affects gut balance
• Support liver detoxification (which works with your gut to clear estrogen): eat cruciferous vegetables like broccoli and cauliflower
Final Thoughts
The gut isn’t just about digestion — it’s a key player in how your body handles hormones, pain, and inflammation.
If you’re struggling with endometriosis, PCOS, or unexplained hormone symptoms, supporting your gut might be an empowering place to start.
Want to Learn More?
Here are some helpful articles and research:
• The Gut Microbiome and Estrogen Metabolism – NIH
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471213/
• Gut Microbiota and Endometriosis – Scientific Reports
https://www.nature.com/articles/s41598-019-39645-2
• How the Gut Influences Hormones – Integrative Medicine Journal
Join Us: Make a Difference Today
Your support can transform lives. Every donation helps us fund research, advocate for better care, and provide essential grants to women facing debilitating conditions.
Join Us: Make a Difference Today
Your support can transform lives. Every donation helps us fund research, advocate for better care, and provide essential grants to women facing debilitating conditions.
New Breakthroughs For Endometriosis
Hope on the Horizon: Breakthroughs in Endometriosis Research
Living with endometriosis or PCOS or fibroids (or any of the other hormone related, immune system diseases) can feel isolating, frustrating, and hopeless, especially for women who are actively fighting symptoms. We have previously highlighted the delay, dismissal and pain that is part of the experience for many of these women. BUT we also want to bring hope by saying that the landscape is starting to shift. Across the globe, researchers are unlocking new discoveries, philanthropists are investing boldly in women’s health, and for the first time in decades, there’s momentum toward real change. We hope this fills you with HOPE today and helps you to know that you are seen and cared for!
Here’s a look at some of the most hopeful developments reshaping the future of endometriosis care — and why we’re optimistic. (AND why we are doing our own research to know the best and most impactful places to invest our dollars!)
New Science Lighting the Way
Moving beyond hormones and surgery
Most current endometriosis treatments rely on hormonal suppression or invasive surgery — options that often come with serious side effects and don’t prevent recurrence or offer a cure.
But a new wave of research is aiming to change that.
Dichloroacetate (DCA), a metabolic drug once used for mitochondrial disorders, is showing surprising promise. In early clinical trials, it reduced lesion size and eased pain in many participants.
“This is the first time we’ve seen a drug target the energy metabolism of endometriosis cells. It’s a potential game-changer,”
— Professor Andrew Horne, University of Edinburgh
HMI-115, a monoclonal antibody targeting the prolactin receptor, is showing significant reductions in pain in Phase II trials.
“The fact that it’s non-hormonal and well tolerated could transform quality of life for millions,”
— Dr. Thomas D’Hooghe, Global Head of Reproductive Medicine R&D at Merck
More than 20 novel therapies are in development, many focused on immune and inflammatory pathways rather than hormones alone. This could lead to disease-modifying treatments, not just symptom control.
Faster, earlier diagnosis
Delays of 7–10 years from symptom onset to diagnosis are still common. That may soon change.
Big-data work at UCSF has identified patterns in millions of health records that could flag endometriosis earlier.
“We’re using artificial intelligence to see what no single doctor could spot in a lifetime,”
— Dr. Marina Sirota, UCSF Institute for Computational Health Sciences
In Australia, researchers are testing a blood-based biomarker panel that could detect endometriosis non-invasively.
New AI-assisted MRI tools are learning to identify endometriosis lesions with accuracy that rivals expert radiologists.
Dedicated research hubs
In May 2025, the Seckin Endometriosis Research Center opened at Cold Spring Harbor Laboratory, powered by a $10 million gift from the Endometriosis Foundation of America (EndoFound) and matched with another $10 million in institutional funding.
“We are building the infrastructure that has been missing in this field for decades. This is how you accelerate cures,”
— Dr. Bruce Stillman, President, Cold Spring Harbor Laboratory
Philanthropy Is Fueling Breakthroughs
After decades of neglect, private donors are helping rewrite the story of women’s health.
The Bill & Melinda Gates Foundation has pledged $2.5 billion through 2030 toward R&D in women’s health, explicitly including gynecologic conditions like endometriosis.
WHAM (Women’s Health Access Matters) has launched its annual Edge Awards to fund early-career researchers focused on endometriosis, PCOS, and menopause.
The Ainsworth family in Australia donated $50 million to launch the Ainsworth Endometriosis Research Institute at the University of New South Wales — the largest known single gift for endometriosis research to date, with the goal of accelerating the understanding, diagnosis and treatment of endometriosis through “integrated research and global collaboration.”
Melinda Gates donated $100 Million to women’s health in order to accelerate research. She emphasized what so many of us have known and live with the consequences of: women’s diseases have been neglected.
This surge in philanthropy is helping fill the gap where public funding has long fallen short. And the list above is not complete, there are many smaller efforts (like Our Daughters Foundation) that seek to fund research, grants for care, and raise awareness.
“Private investment is finally catching up to the urgency patients have always felt. These dollars are helping researchers pursue the bold, risky ideas that government grants often overlook,”
— Dr. Stacey Missmer, Harvard T.H. Chan School of Public Health
Stories of Hope
Beyond the data and dollars, these breakthroughs are already changing lives.
Ella, diagnosed at 14, was one of the youngest participants in the EPiC DCA trial. After years of missing school and friends, she finally began to get her life back.
“It’s like someone turned the volume down on my pain. I can go to class, see friends, be me again.”
Marisol, who endured five surgeries before finding relief with a newer oral therapy, says:
“For the first time in years, I’m planning my future without fear that pain will ruin it.”
We have also featured stories of hope on our pages to show you that you are not alone in your suffering and we are getting closer to understanding this disease.
🌱 Why We’re Hopeful
Endometriosis research is moving from a trickle to a tide, it’s a slow tide and we have a ways to go, but we are moving in the right direction. More of us are making noise, advocating and giving so that we can make a difference now and for our daughters in the future.
New, non-hormonal therapies are emerging.
Faster, less invasive diagnostics are within reach.
Philanthropy and private investment are pouring unprecedented resources into this space.
And most importantly, patients’ voices are finally driving the agenda.
At Our Daughters Foundation, we believe this momentum is just the beginning. The more we invest in understanding this disease — from immune pathways to diagnostic tools — the faster we can build a future where girls and women no longer lose years to pain. It’s a great time to get involved and actually see positive outcomes!
Join the Momentum
Every gift matters. Every conversation matters.
Together, we can help ensure this moment becomes a movement — and that every daughter has a future free from these often debilitating conditions and diseases.
